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According to those data, melatonin could improve sciatic nerve conduction parameters, elevate total protein concentration and upregulate the SOD and catalases activity in rat sciatic nerves when injected intraperitoneally after irradiation

In addition, mature myeloid immune cells display altered phenotypes and functions with elevated production of proinflammatory cytokines such as TNF- and IL-6, which are closely related to age-related senescent inflammation, termed senoinflammation

Neutrophil function is thought to be compromised in older adults, as indicated by increased morbidity and death caused by bacterial infections with advancing age [122]

Funding This work was supported by the National Natural Science Foundation of China (82270386, 82070252, and 8207025), the Zhejiang Provincial Medical and Health Science and Technology Plan (2023RC020), and the Zhejiang Provincial Natural Science Foundation (LR21H020001)